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Front cover illustration

Streaked-culture of Streptomyces coelicolor A3(2) strain M145, a producer of the polyketide antibiotic actinorhodin, which has a unique dimeric structure with two benzoisochromanequinone chromophores connected by a C-C bond. Its acid-base indicator properties (red under acidic conditions and blue under basic ones) provide a convenient method of actinorhodin detection, leading to the first discovery of the genes encoding a type II polyketide synthase. S. coelicolor A3(2) is the most genetically characterized streptomycete, with a complete genome sequence, and also serves as a useful host for heterologous expression of genes of interest from other actinomycetes. Photo courtesy Koji Ichinose and Makoto Ozawa, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan. See the paper by Ichinose et al. on pp. 1633-1645.