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Front cover illustration

Colonies of Streptomyces coelicolor A3(2) producing droplets of the blue-pigmented antibiotic actinorhodin. The droplets sit on the surface of the colonies due to the hydrophobic nature of the aerial hyphae and spores. The production of antibiotics and the developmental cycle of S. coelicolor is complex and its regulation in part is governed by the actions of two-component signal transduction pathways. Photograph courtesy Dr Paul A. Hoskisson, John Innes Centre, Norwich, UK. See the review by Hutchings et al. in this issue, pp. 2795-2806.