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Front cover illustration

Simulated microbial biofilm containing cells in three states: live (yellow), dead (red) and persister (blue). This structure was generated by a three-dimensional computer model of biofilm dynamics. Persisters occupy a hypothetical state in which cells are much less susceptible to killing by antimicrobial agents. Persister cell formation may contribute to the stubborn persistence of biofilm fouling and infections. Image courtesy Jason Chambless and Phil Stewart, Center for Biofilm Engineering, Montana State University. See the article by Roberts & Stewart in this issue, pp. 75-80.