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Front cover illustration

Polar location of a type IV secretion apparatus. The image shows two VirB proteins, components of the Agrobacterium type IV secretion apparatus, forming a protein complex at cell poles, indicated by a yellow focus. Bacteria labelled with an antibody probe show either a VirB7-specific polar green focus or a VirB8-specific polar red focus. Image courtesy Drs R. Kumar, P. Judd and A. Das, University of Minnesota, USA. See the paper by Judd et al. in this issue, pp. 3483-3492.