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Front cover illustration

Time frames from a computer simulation of biofilm detachment induced by the enzymic disruption of the EPS matrix used to evaluate novel strategies for biofilm control. An area of 1 mm², initially covered with microbial biofilm, is shown with dispersion at 0.1, 1.4, 2.2 and 2.5 h (from top to bottom) in the presence of a detachment-promoting agent which alters the cohesiveness of the EPS. Bacterial cells are coloured blue; EPS is coloured grey in its natural cohesive state and red in its compromised state. Image courtesy Dr J. B. Xavier, Center for Biofilm Engineering, Montana State University, USA, and TU Delft, The Netherlands. See the paper by Xavier et al. in this issue, pp. 3817-3832.