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Front cover illustration

Immunofluorescent staining of human lysosomal membrane glycoprotein 1 within HeLa cells infected with Salmonella enterica serovar Typhimurium reveals host-derived filamentous structures, called Salmonella-induced filaments (Sif). The Sif is a unique and striking result of S. enterica-directed manipulation of vacuolar trafficking in macrophages as well, and is a portent of Salmonella virulence. The Sif phenotype is mediated by certain translocated effectors of the Type III secretion system encoded by Salmonella Pathogenicity Island 2. Two of these effectors also provide protection against macrophage oxidants, as demonstrated by a genetic approach detailed in the paper by Suvarnapunya & Stein published in the February 2005 issue of Microbiology, pp. 557-567. Image courtesy A. E. Suvarnapunya and M. A. Stein, Lab of Infection Biology, The Rockefeller University, and Department of Microbiology and Immunology, University of Texas Health Science Center, USA.