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Front cover illustration

Pseudomonas aeruginosa PAK (green) type IV pili (T4P)-mediated binding to cultured IB3 human cystic fibrosis respiratory epithelial cells (diam. 15-20 �m) with phalloidin (red)-stained actin fibres. Bacteria attached to the host cells form a T4P tip-to-tip network. Image courtesy A. Yu, Research Institute, Hospital for Sick Children, Toronto, Canada. See the paper by Emam et al. in this issue, pp. 2789-2799.