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Front cover illustration
Circular optical map of Escherichia coli O157 : H7 isolate EC4045 from the September 2007 US spinach outbreak. Of 28 chromosomal polymorphic sites discussed by Kotewicz et al. in the paper in this issue (pp. 1720-1733), more than seven discriminative markers including sites 3, 5, 10, 11 (O-islands 43, 45, O and R), 18, 19 and near site 21 were identified in multiple outbreak isolates. Image courtesy M. Kotewicz, Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD, USA, and OpGen Inc., Madison, WI, USA.
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